Lakers vs. Pistons odds, prediction, line, and time are set for a key interconference showdown on Tuesday night. 

The Los Angeles Lakers (20-10) host the East-leading Detroit Pistons (24-8), with Detroit favored by 2.5 points and the total set at 232.5 points. 

Tipoff is at 10:30 p.m. ET at the Arena, broadcast on the local Lakers network.

Lakers vs. Pistons Odds, Prediction, Line, Time: The Betting Model's Edge

When analyzing the Lakers vs. Pistons odds, prediction, line, time, the SportsLine Projection Model, which simulates every NBA game 10,000 times, offers key insights. The model, on a 32-14 roll on top-rated NBA spread picks, has simulated this matchup extensively and revealed its betting predictions.

Key Factors and Model's Picks:

·         The Model's Lean: The model strongly favors the Under (232.5 total points). This aligns with recent trends: the Lakers have stayed under in their last two games, and the Under is 5-2 in Detroit's last seven.

·         Why the Under? The pick is driven by Detroit's elite defense (ranked 2nd in defensive rating) facing a Lakers team missing two key starters: Austin Reaves (calf) and Rui Hachimura (calf), who combine for nearly 40 points per game. Both teams also rank in the bottom 10 for three-point shooting, which could slow scoring.

Read also: Nuggets' Nikola Jokic Suffers Knee Injury vs. Heat

·         Spread Pick: The model has also generated a specific against-the-spread pick that it projects will hit in over 50% of its simulations. For that proprietary pick, you need to visit SportsLine.

Game Context and Injuries

The Lakers are coming off a dominant 125-101 win over Sacramento, while the Pistons have lost two straight. Detroit swept the season series last year. The absence of Reaves and Hachimura for Los Angeles significantly impacts their offensive firepower against a stifling Pistons defense, a central factor in the model's Under prediction.

Source Information:

This betting preview and model analysis is derived from the data-driven projections and picks published by SportsLine.

You can see the model's specific against-the-spread pick and full breakdown here:
Lakers vs. Pistons odds, prediction, line, time: 2025 NBA picks for Tuesday, Dec. 30 from proven model